Course Title: Clinical biochemistry (2) Course Code: CLS 368 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: 2 Last Revision Date: 1/1/1438 A. General information about the course: 1. Course Identification 1. Credit hours: (3) 2 T + 1 P 2. Course type A. ?University ?College ? Department ?Track ?Others B. ? Required ?Elective 3. Level/year at which this course is offered: (level 6/year 3) 4. Course general Description: By the end of this course, the students have to improve their knowledge about the renal functions, liver functions, cardiac functions, GIT functions and endocrine functions; and abnormalities correlates with these systems. The student should be able to use the equipment in the laboratory to get accurate results enable him easily to interpret the results of the parameters in the laboratory. 5. Pre-requirements for this course (if any): Clinical biochemistry (1) CLS 353 6. Co-requisites for this course (if any): NA 7. Course Main Objective(s): Upon successful completion of this course, the student should be able to: 1. Discuss physiology of kidney, mechanisms of fluid maintenance & electrolytes balance. And predict laboratory parameters in acute and chronic status. 1. Discuss physiology, synthetic, storage, excretory and detoxifying functions of liver. And predict laboratory findings of jaundice, hepatitis, cirrhosis, cholestasis, and gall stone in chronic and acute status. 2. Discuss the lipids and lipoproteins profiles metabolism, disorders, and correlation with cardiac abnormalities. 3. Recognize the correlation of troponin and myoglobin with myocardial infarction. 4. Discuss the malabsorption, lactose Intolerance and Occult Blood to assess GIT system, and assess pancreatic function. 5. Discuss classification and function of hormones and regulation assessing endocrine systems in health and diseases. 6. Use the different principles and techniques for testing of analytes. 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 60 100% 2 E-learning 3 Hybrid • Traditional classroom • E-learning 4 Distance learning 3. Contact Hours(based on the academic semester) No Activity Contact Hours 137. Lectures 30 138. Laboratory/Studio 30 139. Field 140. Tutorial 141. Others (specify) Total 60 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Describe the basic information about systematic clinical biochemistry. K1 • Lectures are designed to develop the Theoretical exams would contain: Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 1.2 Recognize pathological mechanisms to aid in assessing organ functions and interpreting laboratory results K2 directions for extra reading by the students on the topics. • Guiding students to using references to extract information's. • Discussion of the previous topic. • Interpret of the lecture's outcome every week. • Report and comment on cases study. • Objective questions (Factual recall, illustrative and/or extended MCQs & fill in blanks). • Short essay questions • Long essay questions 2.0 Skills 2.1 Apply the operation of automated equipment in the clinical chemistry Laboratory. S1 • Discussions during formal lectures and /or seminars. • Discuss the theory pre and post the practical work. • interpret the findings of laboratory investigations Follow up within the practical sessions: • Objective Structured Practical Examination (OSPE). • Problem solving questions 2.2 Interpret theoretical information for interpretation of laboratory results. S2 2.3 Correlate laboratory parameters to assess chronic or acute disorders to help predicting findings in renal, liver, cardiac, S3 Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods gastrointestinal, and endocrine systems 3.0 Values, autonomy, and responsibility 3.1 Generate teamwork activities, sharing of personal ideas, and making group discussion. V1 • Group discussion in theory and practical. • Group and individual internet search and analysis for selected topics • Class discussions. • Instructor evaluation and support activity participation in lectures and practical. • Regular reports. • Assignments and Homework. C. Course Content No List of Topics Contact Hours 53. Urinary System Function 4 2. GFR & Clearance of substance (NPN Substances) 4 3. Renal Diseases 4 4. Evaluation of Renal function 4 5. Liver Function 4 6. Liver Jaundice & diseases 4 7. Evaluation of liver functions 4 8. Cardiac system function 4 9. Evaluation of cardiac markers 4 10. GIT and pancreatic system: functions and diseases 4 11. Evaluation of GIT and pancreatic functions 4 12. Endocrine system: Introduction to Hormones and Pituitary Function 4 13. Adrenal Function & Gonadal Function 4 14. Thyroid Gland & Calcium Homeostasis and Hormonal Regulation 4 15. Biochemical laboratory findings in endocrine function 4 Total 60 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 91. Continuous assessment (Quizzes, Case studies, presentations, Discussion, Journal club, etc.) All around semester 5% 92. Midterm examination (written) Week 8-9 15% 93. Assignment submission Week 12 5% 94. Lab report Week 14 5% 5. Practical exam Week 15-16 30% 6. Final written examination Week 17-18 40% *Assessment Activities (i.e., Written test, oral test, oral presentation, group project, essay, etc.). E. Learning Resources and Facilities 1. References and Learning Resources Essential References 1. Michael L. Bishop et.al.(2014) Clinical chemistry principles, procedures, correlations. Lippincott. 2. Marshal WJ.(1997). Clinical chemistry; 3rd edition. Mosby. 3. Varley H.(2002). Practical clinical biochemistry; 4th edition. Arnold. Supportive References 1. Clinical Biochemistry (1st ed.). (2016). Charles University. 2. Carl A. Burtis; Edward R. Ashwood. (2015) Tietz fundamentals of clinical chemistry. 4th edition. Saunders. Electronic Materials 1. Youtube. https://www.youtube.com/ 2. Google images. https://www.google.com.sa/ 3. Taibah University Library e-Book database. https://www.taibahu.edu.sa/Pages/AR/Sector/SectorPage.aspx ?ID=47 4. Learn science at Nature (scitabe) http://www.nature.com/scitable 5. http://www.clinchem.org/ Other Learning Materials 1. Selected films/video clips. 2. Journal of clinical chemistry. 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) Lecture room. Chemistry lab. Technology equipment (projector, smart board, software) Data show. Laptop. Internet accessibility. Other equipment (depending on the nature of the specialty) Spectrophotometer - Water bath - Pipettes - (yellow & blue tips) - Vortex - Sensitive balance - Protein electrophoresis (with full facilities) - Flame photometry - ELISA - Blood gas analyzer - Centrifuge - Reagents - Eppendorf tubes - Gloves - Gauze – Tissue papers. F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Instructor ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Quality of Learning resources Instructor Student ü Course Report. ü Course Evaluation Survey (CES) Achievement of Course Learning Outcomes Instructor Students ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) ü Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor ü Course Report ü Grade Report Analysis ü Course Evaluation Survey (Indirect) Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)