Course Title: Medical Biochemistry 2 Course Code: CLS 244 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: 2 Last Revision Date: 01/02/1438 AH A. General information about the course: 1. Course Identification 1. Credit hours: (3) 2 T + 1 P 2. Course type A. ?University ? College ? Department ?Track ?Others B. ? Required ?Elective 3. Level/year at which this course is offered: (4th Level/2nd Year) 4. Course general Description: The main purpose of the course is to enhance the students by the knowledge and concepts of biochemistry in addition to their clinical correlation. The course outlines the biosynthesis of heme and its disorders, the structure and function of nucleic acids and its metabolism and associated disorders. Also, the course focuses on mechanism of hormonal actions as well as the metabolic function of hormones, vitamins and minerals and their disorders. It will teach students how to handle the biological samples to be measured in the laboratory. The student should be able to use the equipment in the biochemistry laboratories to get an accurate result. Student should be able to interpret the results of the biochemical parameters tested in the laboratories. 5. Pre-requirements for this course (if any): Medical Biochemistry 1 (CLS 233) 6. Co-requisites for this course (if any): None None 7. Course Main Objective(s): 1. Understand heme metabolism and hyperbilirubinemia. 2. Describe nucleotides metabolism especially in relation to inborn errors of metabolism and metabolic diseases. 3. Demonstrate structures, functions and mechanisms of action of hormones. 4. Illustrate role of hormones, vitamins and minerals in regulation of metabolism. 5. List diseases caused by deficiency, excess of hormones vitamins and minerals 6. Validate improvement in the affective traits of organizational skills, work habits, attitude, interpersonal skills, and problem-solving ability 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 60 100% 2 E-learning 3 Hybrid • Traditional classroom • E-learning 4 Distance learning 3. Contact Hours(based on the academic semester) No Activity Contact Hours 76. Lectures 30 77. Laboratory/Studio 30 78. Field 79. Tutorial 80. Others (specify) Total 60 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Describe the basic information and disorders of heme breakdown, bilirubin formation, nucleic acid metabolism, hormones, vitamins, and minerals. K1 Interactive lecture -Small Group discussion -Assignment Written exams (MCQs, EMQs and Essay) -Assignment Evaluation using rubrics 1.2 Develop theoretical information, patients care through critical thinking for the importance and biochemistry of vitamins, K3 Interactive lecture -Small Group discussion -Assignment Written exams (MCQs, EMQs and Essay) Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods minerals, and hormones in living body. -Assignment Evaluation using rubrics 2.0 Skills 2.1 Demonstrate professional skills in using technology in communication and research. Develop oral presentation, teamwork skills and share personal ideas and thoughts. S4 -Tutorial -Group discussions -Assignment -Presentations evaluation using rubrics -Marks for class activity. -Assignment Evaluation using rubrics. 2.2 Perform different laboratory procedures and biochemical experiments and master the report writing process for each experiment. S1 - Practical sessions - Lab. demonstration - Group discussions. - Problem solving activities. - Tutorials -Objective structured practical examination (OSPE). -Problem solving questions. -Group and individual evaluation of the internet searches. 3.0 Values, autonomy, and responsibility 3.2 Adjustment and use of lab. equipment efficiently V2 - Small Group discussion - Practical sessions. - Students Prepared Presentations (SPP). Lab demonstration - Presentation s evaluation using rubrics - Assignment Evaluation using rubrics 3.3 Prepare working reagents and measure the sample using equipment within the context of the legal and professional framework. V1 - Small Group discussion - Practical sessions. - Students Prepared Presentations (SPP). Lab demonstration - Presentation s evaluation using rubrics - Assignment Evaluation using rubrics C. Course Content No List of Topics Contact Hours 17. - Biosynthesis of heme and its disorders. - Catabolism of heme and bilirubin disorders. 6 18. - Biosynthesis of purine nucleotides and its disorders. - Catabolism of purine nucleotides and its disorders. 6 3. - Biosynthesis of pyrimidine nucleotides and its disorders. - Catabolism of pyrimidine nucleotides and its disorders. 6 4. - Classification and chemistry of hormones and mechanisms of hormonal actions. 3 5. - Regulation of hormonal secretions. - Hypothalamus-pituitary axis. 4 6. - Hypothalamus-pituitary axis and its disorders. - Adrenal cortex hormones and its disorders. 4 7. - Adrenal medulla hormones. - Male and female sex hormones. 4 8. - Thyroid & parathyroid, Pancreatic, Gastrointestinal, and hormones. 3 9. - Water- soluble vitamins. 4 10. - Fat- soluble vitamins. 6 11. - Mineral metabolism. - Trace element metabolism. 6 12. - Mineral metabolism. - Trace element metabolism. 4 13. - Mineral metabolism. - Trace element metabolism. 4 Total 60 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 46. Continuous assessment All over semester 5% 47. Midterm examination (written) Week 8-9 15% 3. Assignment submission Week 12 5% 4. Lab report Week 14 5% 5. Practical exam Week 15-16 30% 6. Final written examination Week 17-18 40% E. Learning Resources and Facilities 1. References and Learning Resources Essential References • David L. Nelson, Michael M. Cox. (2012). Lehninger Principles of Biochemistry, 6th Edition. • Denis R. Ferrier. (2013). Biochemistry (Lippincott Illustrated Reviews Series). 6th Edition. Supportive References • Victor Rodwell, David Bender, Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil. (2015). Harpers Illustrated Biochemistry,30th Edition. • Said Oraby. Oraby's Illustrated reviews of Biochemistry, Twelfth edition. Egypt, 2010. • Ramnik Sood. Medical Laboratory Technology (MLT) Methods and Interpretations, Jaypee Ed., 2009. Electronic Materials The Journal of Biochemistry (http://jb.oxfordjournals.org/ ) • http://pubs.acs.org/journal/bichaw • http://www.sciencedirect.com/ • The Biology Project (from the University of Arizona): • http://www.biology.arizona.edu/default.html • http://www.ncbi.nlm.nih.gov/pubmed • https://nutritionandmetabolism.biomedcentral.com Other Learning Materials Multimedia associated with the textbook and the relevant websites. 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) - Lecture room - Laboratories for practical sessions Technology equipment (projector, smart board, software) - Computers - Internet access - Smart Board (preferred) - Projector Other equipment (depending on the nature of the specialty) - Data show - White board - Incubator - Lab tools, kits, and instruments. F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Instructor ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Quality of Learning resources Instructor Student ü Course Report. ü Course Evaluation Survey (CES) Achievement of Course Learning Outcomes Instructor Students ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) ü Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor ü Course Report ü Grade Report Analysis ü Course Evaluation Survey (Indirect) Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)