Course Title: Clinical Practice 3 (Histopathology and Molecular biology) Course Code: CLS 486 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: 2 Last Revision Date: 06/02/1438 AH A. General information about the course: 1. Course Identification 1. Credit hours: (3 hours) 3 P 2. Course type A. ?University ?College ? Department ? Track ?Others B. ? Required ?Elective 3. Level/year at which this course is offered: (Level 8/ Year 4) 4. Course general Description: This course is designed to provide students with the knowledge and laboratory skills needed in clinical practice at a hospital setting within Histopathology and Molecular Science laboratories at a specialist graduate level. Learning objectives of the course will be including specimen collection and transporting of medically important biopsies, cellular materials, and body fluids samples. Also, registering, and interning data in relation into hospital system before fixing in an appropriate chemical and/or processing them for microscopical or other suitable instrumentation for the appropriate analysis will be the major learning outcomes of this course. The course is practical nature that supposed to be taken in hospitals for acquiring the practical skills of achieving tissue samples analysis and providing the requested most accurate information in an easy way to be used by the clinician’s team in the relevant medical department. 5. Pre-requirements for this course (if any): Histopathological Techniques CLS 248 & Molecular Biology CLS 396 6. Co-requisites for this course (if any): None 7. Course Main Objective(s): By the end of this course the student should be able to: 8. Demonstrate scientific/technical knowledge in histological, cellular, molecular oncology and science related. 9. Expose students to a real environment of routine cytology and histopathology, molecular biology preparations and processing for assessment and microscopical examination in a hospital setting. 10. To correlate between the requested analysis pathological underlining investigations and the technique to be used. 11. Understanding of molecular examinations for human diseases that related to genetic abnormalities and mutations. 12. Knowledge of disease complicity interpretation and effectively communicating with other healthcare providers. 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Practical sessions/Tutorials 90 100% 2 E-learning 3 Hybrid • Traditional classroom • E-learning 4 Distance learning 3. Contact Hours(based on the academic semester) No Activity Contact Hours 182. Lectures - 183. Laboratory/Studio/Tutorials 45 184. Field 45 185. Tutorial - 186. Others (specify): case studies Total 90 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Recall knowledge and skills in histopathology and molecular biology, including understanding various disease processes and causes K2 Hospital visits, Lectures & lab practice Quizzes Hospital visits reports Final Exam Practical exams 1.3 Explain routine and specific procedures this include; histopathological, cytological, and molecular investigations K3 Hospital visits, Lectures & lab practice Quizzes Hospital visits reports Final Exam Practical exams 2.0 Skills 2.1 Analyze genetic predisposing to human disease S2 Active engaging, Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods Lectures and reading on the topic from Refs, and directed webpages C/studies, MCQ and L/S assays 2.2 Realize the appropriate approach to a requested analysis and the tissue, cytology, body fluid specimens obtained for examination/analysis and the technique to be used. S2 Hospital visits, Lectures and reading on cases and from recon Refs Quizzes Hospital visits reports Final Exam Lab exams 3.0 Values, autonomy, and responsibility 3.1 Judge the received sample/biopsy relevance to patient’s clinical detail /query, and communicate effectively at all levels V1 Hospital visits, Lectures and reading on cases and from recon Refs MCQ, short and Long Assays, Practical, Group discussion, case studies, and exam assays 3.3 Communicate with the health staff inside the lab for personal ideas and thoughts to make effective teamwork collaboration. V3 Group and individual internet search and analysis for selected topics. C. Course Content No List of Topics Contact Hours 69. Handling clinical samples used in Histology and Molecular labs 6 70. Practice of surgical pathology (specimen processing) 6 3. Practice of surgical pathology (specimen stains and interp.) 6 4. Specimens processing for Cytopathology diagnostics 6 5. Advanced Tissue Biomarkers and Cancer Diagnosis 6 6. Histopathology & Cytopathology case discussions 6 7. Molecular diagnostics: Sanger sequencing and nomenclature guideline 6 8. Training on RT-PCR and qRT-OCR assay to detect RNA expression of a gene 6 9. Molecular cytogenetics diagnostic: FISH and Array-CGH 6 10. Advanced molecular diagnostic: High throughput sequencing 6 11. Using noninvasive prenatal testing (NIPT) to detect chromosomal abnormalities 6 12. Hospital visit -1 6 13. Hospital visit -2 6 14. Hospital visit -3 6 15. Hospital visit -4 6 Total 90 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 126. Case study-based exam Week 10 30 % 3. Hospital report All over the course 10 % 4. Practical exam Week 15-16 30% 5. Final written examination Week 17-18 30% *Assessment Activities (i.e., Written test, oral test, oral presentation, group project, essay, etc.). E. Learning Resources and Facilities 1. References and Learning Resources Essential References • Bancroft's Theory and Practice of Histological Techniques. Pranab Dey · 2018 • Molecular Diagnostics Edited by Contributors, Wayne W. Grody, M.D., Ph.D., Robert M. Nakamura, M.D., Charles M. Strom, M.D., Ph.D., and Frederick L. Kiechle, MD, PhD. ISBN: 978-0-12-369428-7 Supportive References • Pathologic bases of disease; Robbins, and Cotran, 10th edition, by Richard N Mitchell et al, Elsevier, 2023 • Cytopathology edited by Behdad Shambayati, Oxford, latest version • Molecular Diagnostics: For the Clinical Laboratorian William B. Coleman, Gregory J. Tsongalis Springer, 2006 - Medical - 567 page Electronic Materials Pathology Outlines, https://www.pathologyoutlines.com/ Other Learning Materials Online university videos and material 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) University Hospital, local hospitals Items Resources Technology equipment (projector, smart board, software) Projectors, white board etc.. Other equipment (depending on the nature of the specialty) Histopathology and Molecular biology laboratory equipment’s (e.g. Microtomes, Stainers, PCR … etc F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Instructor ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Quality of Learning resources Instructor Student ü Course Report. ü Course Evaluation Survey (CES) Achievement of Course Learning Outcomes Instructor Students ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) ü Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor ü Course Report ü Grade Report Analysis ü Course Evaluation Survey (Indirect) Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)