Course Title: Medical Biochemistry Course Code: CBCH 101 Program: Bachelor of Nursing Program Department: Basic Medical Sciences College: Medicine (Offering), Nursing (Beneficiary) Institution: Taibah University Version: version 2 Last Revision Date: 2015 A. General information about the course: 1. Course Identification 1. Credit hours: ( 3 CH ) 2 T + 1 P 2. Course type A. ?University ? College ?Department ?Track ?Others B. ? Required ?Elective 3. Level/year at which this course is offered: Level: 1 Year: 1 4. Course general Description: The biochemistry course is designed to provide the nursing student with an overview of normal metabolism of the body, description of the integration of biochemical functions, and knowledge about the biochemical bases of diseases that aids in interpretation of symptoms and treatment. This course is concerned with the study of disorders in protein, lipid, and mineral metabolism as well as electrolytes, blood gases and acid base balance. This course introduces the students to the importance of the plasma levels of different biochemical markers and their role in the diagnosis and follow-up of different diseases. Furthermore, it provides the student with an idea about the genetic background of different metabolic disorders. 5. Pre-requirements for this course (if any): None 6. Co-requisites for this course (if any): None 7. Course Main Objective(s): Upon completion of this course the student should be able to. 1. Illustrate the metabolic basis of disease. 2. Identify the chemical structure of different food stuffs, enzymes and molecular biology 3. Demonstrate the normal pathways of metabolism, such as the biosynthesis of large molecules, the metabolism of small molecules involved in the generation and storage of energy, and the use of molecular genetics in diagnosis and treatment of disease. 4. Discuss the role of biochemistry in disease and clinical treatments. 5. Explain the clinical significance of determination of plasma levels of different biochemical markers. 6. Detect abnormal results and confirm the presence of disease states. 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 0 0 2 E-learning 0 0 3 Hybrid ? Traditional classroom ? E-learning 48 12 80% 20% 4 Distance learning 0 0 3. Contact Hours (based on the academic semester) No Activity Contact Hours 11. Lectures 30 12. Laboratory/Studio 30 13. Field 0 14. Tutorial 0 15. Others (specify) 0 Total 60 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of PLOs aligned with program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Describe the nature, mechanism of action and types of enzymes K2 Interactive lectures. Case studies. Group discussion. Seminars. MCQs. Quiz 1. Quiz 2. Final exam. 1.2 Identify the biochemical metabolic pathways under ? physiological condition. K2 1.3 Explain the effects of inborn errors of metabolism and other ? diseased states resulting from molecular imbalances K2 1.4 Identify the different types of nucleic acids ? structure and function K2 2.0 Skills 2.1 Correlate biochemical laboratory findings of different diseases with clinical signs and symptoms. S3 Interactive lectures. Problem Based Learning. Problem solving questions. MCQs. Written exams. 2.2 Appraise the clinical significance of determination of blood levels of different biochemical markers and urine report Code Course Learning Outcomes Code of PLOs aligned with program Teaching Strategies Assessment Methods 2.3 Perform blood sampling and laboratory tests of analytes in blood and urine samples S1 Group discussion. 2.4 Handle the equipment carefully S2 3.0 Values, autonomy, and responsibility 3.1 Demonstrate creativity and time management abilities. V1 Small group discussion. give supporting websites. give supporting books to study & read. Continuous evaluation of students. communications and participation during class. Continuous discussions with student (Oral discussion). Written exams 3.2 Show professional responsibility and respect the compliance to work through systems V3 C. Course Content No List of Topics Contact Hours 17. Introduction to biochemistry. ? Biochemistry & Nursing ? Relationship between Cell Biology and Biochemistry. ? Cell Membrane. ? Transport across Membrane. ? Vitamins and minerals. Lab safety and sampling 4 18. ? Automatic pipetting ? Spectrophotometry Iron metabolism and TIBC 4 3. Enzymes ? Mechanisms of Enzyme Action. ? Introduction to Enzyme. ? Rates of Enzymatic Reaction. ? Factor affecting Enzymatic Reaction. ? Plasma enzymes Total Ck+ CK-MB Liver enzyme. ? Intermediary Metabolism. Bioenergetics and oxidative phosphorylation. 8 4. Carbohydrate Chemistry and Metabolism. ? Carbohydrate Chemistry and classification. ? Digestion and absorption. ? Glycolysis. ? Tricarboxylic Acid Cycle. ? Pentose Phosphate Pathway and NADPH. ? Glycogen Metabolism. ? Gluconeogenesis. Glucose, OGTT and HbA1C 8Lipid Chemistry and Metabolism ? Lipid Chemistry and Classification. ? Digestion and Absorption. ? Fatty Acid Metabolism. ? Cholesterol and steroid. ? Keton Bodies. ? Lipoproteins. ? Phospholipid. Total Lipid profile 8 6. Proteins Metabolism, Structure & Functions ? Structure of Proteins. ? Globular Proteins (e.g. Hemoglobin). ? Fibrous Proteins. Nitrogen Metabolism ? Amino Acids: Disposal of Nitrogen. ? Amino Acid Degradation and Synthesis ? Ammonia transport. ? Nitrogen balance. ? Conversion of Amino Acids to Specialized Products. ? Disorder in metabolism. Practical Application ? Urea & Creatinine - Creatinine Clearance. ? Total protein and Albumin -Separation of Plasma proteins Hb and Hb electrophoresis. 14 7. Integration of Metabolism ? Metabolic Effects of Insulin and Glucagon. ? The Feed/Fast Cycle. ? Diabetes Mellitus. Bilirubin metabolism. 4 8. Hormones ? Classification. Signal transduction. 2 9. Storage & Expression of Genetic Information Nucleotide Metabolism. DNA Structure, Replication, and Repair. RNA RNA Structure. Synthesis and Processing. Protein Synthesis. Regulation of Gene Expression 6 10. Others. Uric acid and gout. Physical characters of urine. Biochemical screening of urine sample. Using strip test for urine analysis. 2 Total 60 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 9. Written Quiz 1 Week 4 10% 10. Midterm Exam Week 8 20% 11. Midterm Practical Exam Week 12 20% 12. Written Quiz 2 Week 14 10% 5. Final Practical Exam Week 16 10% 6. Final Theoretical Exam Week 17 30% *Assessment Activities (i.e., Written test, oral test, oral presentation, group project, essay, etc.). E. Learning Resources and Facilities 1. References and Learning Resources Essential References 1. Champ PC, Harvey RA and Ferrier DR (2012): Lippincott's Reviews of Biochemistry, 4th edition, Lippincott William & Wilkins London lww.com/lippincott-biochemistry 2. Kaplan LA and Pesce AJ (2010): Clinical Chemistry: Theory, Analysis, Correlation, 4th edition , Mosby. Supportive References Murray RK, Granner DK, Mayes PA and Rodwell VW (2010) : Harper's Illustrated Biochemistry: 28th edition , McGraw-Hill companies NewYork, Electronic Materials www.biochemistry4all.com/forums www.com/lippincott-biochemistry. Other Learning Materials Internet access for the computer lab. Online content using Jusur LMS. 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) 1- classrooms. 2- biochemistry laboratory. Technology equipment (projector, smart board, software) 1- data show. 2- smart board. Other equipment (depending on the nature of the specialty) 1-spectrophotometer. 2- automatic pipettes. 3- Chemical kits for different reagents. F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Peer Reviewer Direct Method (Rubrics) Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students’ assessment Faculty Student achievement is verified by the head of the department. Quality of learning resources Students Course Report. Course Evaluation Survey (CES) The extent to which CLOs have been achieved Course Coordinator Direct Method (Rubrics) Indirect Method (Questionnaire on the course by the end of the semester) Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor Course Report Grade Report Analysis Course Evaluation Survey (Indirect) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect) G. Specification Approval COUNCIL /COMMITTEE REFERENCE NO. DATE 6