الكيمياء الحيوية الطبية

Course Title: Medical Biochemistry
Course Code: CBCH 101
Program: Bachelor of Nursing Program
Department: Basic Medical Sciences
College: Medicine (Offering), Nursing (Beneficiary)
Institution: Taibah University
Version: version 2
Last Revision Date: 2015
A. General information about the course:
1. Course Identification
1. Credit hours: ( 3 CH )
2 T + 1 P
2. Course type
A. ?University ? College ?Department ?Track ?Others
B. ? Required ?Elective
3. Level/year at which this course is offered: Level: 1 Year: 1
4. Course general Description:
The biochemistry course is designed to provide the nursing student with an overview of normal metabolism of the body, description of the integration of biochemical functions, and knowledge about the biochemical bases of diseases that aids in interpretation of symptoms and treatment. This course is concerned with the study of disorders in protein, lipid, and mineral metabolism as well as electrolytes, blood gases and acid base balance. This course introduces the students to the importance of the plasma levels of different biochemical markers and their role in the diagnosis and follow-up of different diseases. Furthermore, it provides the student with an idea about the genetic background of different metabolic disorders.
5. Pre-requirements for this course (if any):
None
6. Co-requisites for this course (if any):
None
7. Course Main Objective(s):
Upon completion of this course the student should be able to.
1. Illustrate the metabolic basis of disease.
2. Identify the chemical structure of different food stuffs, enzymes and molecular biology 3.
Demonstrate the normal pathways of metabolism, such as the biosynthesis of large molecules,
the metabolism of small molecules involved in the generation and storage of energy, and the use
of molecular genetics in diagnosis and treatment of disease.
4. Discuss the role of biochemistry in disease and clinical treatments.
5. Explain the clinical significance of determination of plasma levels of different biochemical
markers.
6. Detect abnormal results and confirm the presence of disease states.
2. Teaching mode (mark all that apply)
No Mode of Instruction Contact Hours Percentage
1 Traditional classroom 0 0
2 E-learning 0 0
3
Hybrid
? Traditional classroom
? E-learning
48
12
80%
20%
4 Distance learning 0 0
3. Contact Hours (based on the academic semester)
No Activity Contact Hours
11. Lectures 30
12. Laboratory/Studio 30
13. Field 0
14. Tutorial 0
15. Others (specify) 0
Total 60
B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment
Methods
Code Course Learning Outcomes
Code of PLOs
aligned with
program
Teaching
Strategies
Assessment
Methods
1.0 Knowledge and understanding
1.1 Describe the nature, mechanism of action and
types of enzymes K2
Interactive
lectures.
Case studies.
Group
discussion.
Seminars.
MCQs.
Quiz 1.
Quiz 2.
Final exam.
1.2 Identify the biochemical metabolic pathways
under ? physiological condition. K2
1.3
Explain the effects of inborn errors of
metabolism and other ? diseased states
resulting from molecular imbalances
K2
1.4 Identify the different types of nucleic acids ?
structure and function K2
2.0 Skills
2.1
Correlate biochemical laboratory findings of
different diseases with clinical signs and
symptoms.
S3
Interactive
lectures.
Problem
Based
Learning.
Problem solving
questions.
MCQs.
Written exams.
2.2
Appraise the clinical significance of
determination of blood levels of different
biochemical markers and urine report
Code Course Learning Outcomes
Code of PLOs
aligned with
program
Teaching
Strategies
Assessment
Methods
2.3 Perform blood sampling and laboratory tests
of analytes in blood and urine samples S1 Group
discussion.
2.4 Handle the equipment carefully S2
3.0 Values, autonomy, and responsibility
3.1 Demonstrate creativity and time management
abilities. V1
Small group
discussion.
give
supporting
websites.
give
supporting
books to study
& read.
Continuous
evaluation
of students.
communications
and
participation during
class.
Continuous
discussions
with student (Oral
discussion).
Written exams
3.2 Show professional responsibility and respect
the compliance to work through systems V3
C. Course Content
No List of Topics Contact Hours
17.
Introduction to biochemistry.
? Biochemistry & Nursing
? Relationship between Cell Biology and Biochemistry.
? Cell Membrane.
? Transport across Membrane.
? Vitamins and minerals.
Lab safety and sampling
4
18.
? Automatic pipetting
? Spectrophotometry
Iron metabolism and TIBC
4
3.
Enzymes
? Mechanisms of Enzyme Action.
? Introduction to Enzyme.
? Rates of Enzymatic Reaction.
? Factor affecting Enzymatic Reaction.
? Plasma enzymes Total Ck+ CK-MB Liver enzyme.
? Intermediary Metabolism.
Bioenergetics and oxidative phosphorylation.
8
4.
Carbohydrate Chemistry and Metabolism.
? Carbohydrate Chemistry and classification.
? Digestion and absorption.
? Glycolysis.
? Tricarboxylic Acid Cycle.
? Pentose Phosphate Pathway and NADPH.
? Glycogen Metabolism.
? Gluconeogenesis.
Glucose, OGTT and HbA1C
8Lipid Chemistry and Metabolism
? Lipid Chemistry and Classification.
? Digestion and Absorption.
? Fatty Acid Metabolism.
? Cholesterol and steroid.
? Keton Bodies.
? Lipoproteins.
? Phospholipid.
Total Lipid profile
8
6.
Proteins Metabolism, Structure & Functions
? Structure of Proteins.
? Globular Proteins (e.g. Hemoglobin).
? Fibrous Proteins.
Nitrogen Metabolism
? Amino Acids: Disposal of Nitrogen.
? Amino Acid Degradation and Synthesis
? Ammonia transport.
? Nitrogen balance.
? Conversion of Amino Acids to Specialized Products.
? Disorder in metabolism.
Practical Application
? Urea & Creatinine - Creatinine Clearance.
? Total protein and Albumin -Separation of Plasma proteins
Hb and Hb electrophoresis.
14
7.
Integration of Metabolism
? Metabolic Effects of Insulin and Glucagon.
? The Feed/Fast Cycle.
? Diabetes Mellitus.
Bilirubin metabolism.
4
8.
Hormones
? Classification.
Signal transduction.
2
9.
Storage & Expression of Genetic Information
Nucleotide Metabolism.
DNA Structure, Replication, and Repair.
RNA
RNA Structure.
Synthesis and Processing.
Protein Synthesis.
Regulation of Gene Expression
6
10.
Others.
Uric acid and gout.
Physical characters of urine.
Biochemical screening of urine sample.
Using strip test for urine analysis.
2
Total 60
D. Students Assessment Activities
No Assessment Activities *
Assessment
timing
(in week no)
Percentage of Total
Assessment Score
9. Written Quiz 1 Week 4 10%
10. Midterm Exam Week 8 20%
11. Midterm Practical Exam Week 12 20%
12. Written Quiz 2 Week 14 10%
5. Final Practical Exam Week 16 10%
6. Final Theoretical Exam Week 17 30%
*Assessment Activities (i.e., Written test, oral test, oral presentation, group project, essay, etc.).
E. Learning Resources and Facilities
1. References and Learning Resources
Essential References
1. Champ PC, Harvey RA and Ferrier DR (2012): Lippincott's Reviews of
Biochemistry, 4th edition, Lippincott William & Wilkins London
lww.com/lippincott-biochemistry
2. Kaplan LA and Pesce AJ (2010): Clinical Chemistry: Theory, Analysis,
Correlation, 4th edition , Mosby.
Supportive References
Murray RK, Granner DK, Mayes PA and Rodwell VW (2010) : Harper's
Illustrated Biochemistry: 28th edition , McGraw-Hill companies
NewYork,
Electronic Materials www.biochemistry4all.com/forums
www.com/lippincott-biochemistry.
Other Learning Materials Internet access for the computer lab.
Online content using Jusur LMS.
2. Required Facilities and equipment
Items Resources
facilities
(Classrooms, laboratories, exhibition rooms,
simulation rooms, etc.)
1- classrooms.
2- biochemistry laboratory.
Technology equipment
(projector, smart board, software)
1- data show.
2- smart board.
Other equipment
(depending on the nature of the specialty)
1-spectrophotometer.
2- automatic pipettes.
3- Chemical kits for different reagents.
F. Assessment of Course Quality
Assessment Areas/Issues Assessor Assessment Methods
Effectiveness of teaching Peer Reviewer
Direct Method (Rubrics)
Indirect Method (Questionnaire on the
course by the end of the semester)
Effectiveness of Students’
assessment
Faculty Student achievement is verified by the head
of the department.
Quality of learning resources Students Course Report.
Course Evaluation Survey (CES)
The extent to which CLOs have
been achieved
Course
Coordinator
Direct Method (Rubrics)
Indirect Method (Questionnaire on the
course by the end of the semester)
Course Evaluation Survey (CES)
Effectiveness of Assessment Results Instructor
Course Report
Grade Report Analysis
Course Evaluation Survey (Indirect)
Effectiveness of
Students' assessment
Head of the
department
Student achievement is verified by the head
of the department.
Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify)
Assessment Methods(Direct, Indirect)
G. Specification Approval
COUNCIL /COMMITTEE
REFERENCE NO.
DATE
6