Course Title: Hemostasis and coagulopathies Course Code: CLS 364 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: 1 Last Revision Date: N/A A. General information about the course: 1. Course Identification 1. Credit hours: (2) 1 T + 1 P 2. Course type A. ?University ?College xDepartment ?Track ?Others B. x Required ?Elective 3. Level/year at which this course is offered: (6th level/3rd year) 4. Course general Description: This course provides an in-depth exploration of the physiological mechanisms governing hemostasis and understanding of disorders related to hemostatic mechanisms and coagulation pathways. Students will delve into the fundamental aspects of clotting, bleeding disorders, as well as acquiring the basic knowledge & skills required for laboratory diagnosis of different types of coagulopathies and the laboratory control of anticoagulation therapy. 5. Pre-requirements for this course (if any): Hematology 2 (CLS 355) 6. Co-requisites for this course (if any): N/A 7. Course Main Objective(s): • Define hemostasis and list and contrast the three components of hemostasis: extravascular, vascular and intravascular, hypo and hypercoagulable status (McKenzi and clinical hema). • Explain and contrast the role of endothelium and role of platelets in hemostasis (primary hemostasis). • List and describe the Laboratory evaluation of abnormal bleeding due to primary hemostatic defect. • Explain and diagram the fundamentals of coagulation mechanisms and role of platelets in secondary hemostasis. • Describe the Functions of fibrinolysis in hemostasis. • Discuss the laboratory evaluation of coagulation. • List and discuss the Types of vascular abnormalities and their significant lab findings. • Distinguish the quantitative and qualitative platelet disorders and Lab investigations. • Outline Hereditary Hemorrhagic coagulopathies (Hemophilias A, B & C) 1 • Outline Hereditary Hemorrhagic coagulopathies (vWD) 2 • Differentiate Acquired Hemorrhagic coagulopathies (Liver disease, DIC, vitK deficiency, LA) • Describe disorders of fibrinolysis and Laboratory evaluation of abnormal bleeding due to secondary hemostatic defect • Define and describe Hereditary Thrombogenic coagulopathy (Thrombophilia) • Define, list and describe Acquired thrombophilia • Outline laboratory management of anticoagulation therapy (APTT and PT/INR) 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 45 100 2 E-learning 3 Hybrid • Traditional classroom • E-learning 4 Distance learning 3. Contact Hours(based on the academic semester) No Activity Contact Hours 126. Lectures 15 127. Laboratory/Studio 30 128. Field 129. Tutorial 130. Others (specify) Total 45 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Understand normal hemostasis and the three components of hemostasis: extravascular, vascular and intravascular; and hypo- and hypercoagulable state K1 Comprehensive Lectures (to cover the basic principles of hemostasis and coagulopathies,using visuals, diagrams, and multimedia presentations to enhance understanding of complex concepts Break down the information into manageable segments to facilitate learning. - Case-Based Learning (Integrate case studies into the curriculum to illustrate real-life scenarios of hemostasis and coagulopathies. Encourage students to analyze and discuss cases, applying theoretical knowledge to practical situations). - Group discussion (to initiate problem solving challenges among groups) Theoretical exams would contain: • Objective questions (Factual recall, illustrative and/or extended MCQs & fill in blanks). • Short essay questions • Long essay questions 1.2 Describe the primary and secondary hemostasis K2 1.3 Identify clinical and laboratory aspects of hemostatic disorders including hemophilia, thrombosis, DIC, and von Willebrand disease. List and interpret coagulation tests K3 2.0 Skills 2.1 Interpret results from common coagulation tests in patients with hemophilia, vW disease or DIC or thrombophilia. S2 Practical laboratory sessions (hands-on experience will allow students to perform various hematological tests to understand the practical implications of their theoretical knowledge) Case studies (will allow students to analyze lab result and provide accurate interpretation) Practical portfolio Lab reports designed to enable students to recognize, evaluate and challenge their own learning process. - Practical exam - Problem solving questions Case Studies Code Course Learning Outcomes Code of CLOs program Teaching Strategies Assessment Methods 3.0 Values, autonomy, and responsibility 3.1 Stress the importance of ethical considerations when conducting laboratory tests related to coagulopathies. V1 - Comprehensive Lectures - Case-Based Learning - Group discussion - Laboratory demonstration - Study-case problem Assessment of group assignment/ presentation includes a Component for individual contribution. 3.2 Modify variable web sites searching to complement extra information education. V2 C. Course Content No List of Topics Contact Hours 49. Hemostasis definition and the three components of hemostasis: extravascular, vascular and intravascular, hypo and hypercoagulable status 3 50. Role of endothelium and Role of platelets in hemostasis (primary hemostasis). 3 3- The Laboratory evaluation of abnormal bleeding due to primary hemostatic defect 3 4. The Fundamentals of coagulation mechanisms and role of platelets in secondary hemostasis 3 5. The Functions of fibrinolysis in hemostasis 3 6. The laboratory evaluation of coagulation 3 7. Types of vascular abnormalities, their roles in coagulopathy and significant lab findings 3 8. The Quantitative and Qualitative platelet disorders and Lab investigations 3 9. Hereditary Hemorrhagic coagulopathies (Hemophilias A,B and C) 1 3 10. Hereditary Hemorrhagic coagulopathies (vWD) 2 3 11. Acquired Hemorrhagic coagulopathies (Liver disease, DIC, vitK deficiency, LA) 3 12. Disorders of fibrinolysis and Laboratory evaluation of abnormal bleeding due to secondary hemostatic defects 3 13. Hereditary Thrombogenic coagulopathy (Thrombophilia) 3 14. Acquired thrombophilia 3 15. laboratory management of anticoagulation therapy 3 Total 45 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 84. Continuous assessment All over semester 5% 85. Midterm examination (written) Week 8-9 15% 86. - Assignment Week 12 5% 4. Lab report Week 14 5% 5. Practical exam Week 15-16 30% 131. Final theoretical exam Week 17-18 40% *Assessment Activities (i.e., Written test, oral test, oral presentation, group project, essay, etc.). E. Learning Resources and Facilities 1. References and Learning Resources Essential References 6. Hoff brand AV, Pettit JE, PAH Moss (2001). Essential of Hematology. 4th ed, BlackwellScientific Publications, ISBN 0632051531. 7. Sir John V. Deice & Lewis. (2011). Practical Hematology, ISBN10: 0- 443-066. 8. Shirlyn B. McKenzie, PhD, CLS (NCA), (2014) . Clinical Laboratory Hematology,3ed EditioUniversity of Texas Health Science center at San Antonio, Lynne Williams. Supportive References 5. Robert T. Means Jr. MD (Author), Daniel A. Arber MD (Author), Bertil E. Glader MD PhD (Author), & 6 more. Wintrobe’s Clinical Hematology, 15th Edition. 6. Victor Hoffbrand (Editor), Douglas R. Higgs (Editor), David M. Keeling (Editor), Atul B. Mehta (Editor). ISBN: 978-1-118-85432- 7 January 2016 Wiley-Blackwell. Postgraduate Haematology, 7th Edition. Electronic Materials 1. http:// www.med.nagoya-u-ac 2. http:// www.wfh.org/ 3. http:// www.hematology .org/ 4. https://b-s-h.org.uk/ Other Learning Materials as computer-based programs/CD, professional standards or regulations andsoftware 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) Classrooms, Laboratories Technology equipment (projector, smart board, software) Projector, Softboard Other equipment (depending on the nature of the specialty) Water-bath, Centrifuge, Coagulometer, Automatic pipette, Stopwatch, PT, PTT, TT, Fibrinogen assay, Control and normal plasma. F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Instructor ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Quality of Learning resources Instructor Student ü Course Report. ü Course Evaluation Survey (CES) Achievement of Course Learning Outcomes Instructor Students ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) ü Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor ü Course Report ü Grade Report Analysis ü Course Evaluation Survey (Indirect) Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)