Course Title: Hematology I Course Code: CLS 246 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: V2 Last Revision Date: 04/02/1438 AH A. General information about the course: 1. Course Identification 1. Credit hours: (3) 2 T + 1 P 2. Course type A. ?University ?College xDepartment ?Track ?Others B. x Required ?Elective 3. Level/year at which this course is offered: (4th level/2nd year) 4. Course general Description: This course provides the basic knowledge & skills required for laboratory understanding of the blood formation and its components, including hematopoietic stem cells, hematopoietic organs, bone marrow structure and function, erythropoiesis, leukopoiesis, and thrombopoiesis. The course also covers iron and vitamin B12 metabolism, hemoglobin structure and function, classification of anemias, RBCs disorders and WBCs benign disorders. The practical part includes hemocytometry and blood cell count, thin blood film spreading and staining. 5. Pre-requirements for this course (if any): Human Physiology (CLS 124) 6. Co-requisites for this course (if any): N/A 7. Course Main Objective(s): • Describe hemopoiesis, hemopoietic organs and blood cell formation. • Discuss bone marrow function and structure, stages of hemopoiesis in human embryo, fetus and adulthood. • Discuss erythropoiesis, leucopoiesis, thrombopoiesis, and their structure, function, and evaluation. • Discuss Iron and vitamin B12 metabolism. • Perform manual blood cell count using hemocytometer. • Perform thin blood spreading, staining, and recognizing normal blood cells morphology and carrying out differential and absolute cell count. • Discuss hemoglobin formation, structure, function, types, and evaluation. • Define anemia and identify its classification, causes and disorders. • Describe leukocyte types and classify their disorders. 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 60 100 2 E-learning 3 Hybrid • Traditional classroom • E-learning 4 Distance learning 3. Contact Hours(based on the academic semester) No Activity Contact Hours 81. Lectures 30 82. Laboratory/Studio 30 83. Field 84. Tutorial 85. Others (specify) Total 60 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs progr am Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Describe different types of blood cells, their stages of cell formation and the normal and abnormal morphology. K1 Comprehensive Lectures (to cover the basic background of different blood cell formation, using visuals, diagrams, and multimedia presentations to enhance understanding of complex concepts Theoretical exams would contain: • Objective questions (Factual recall, illustrative 1.2 Explain the different types of blood cells functions, the defects and the associated pathophysiology, K2 Code Course Learning Outcomes Code of CLOs progr am Teaching Strategies Assessment Methods clinical outcome. Break down the information into manageable segments to facilitate learning. - Case-Based Learning (Integrate case studies into the curriculum to illustrate real-life scenarios of normal and abnormal blood tests. Encourage students to analyze and discuss cases, applying theoretical knowledge to practical situations). - Group discussion (to initiate problem solving challenges among groups). and/or extended MCQs & fill in blanks). • Short essay questions • Long essay questions 1.3 Discuss the diagnostic tests used to evaluate blood cells including RBCs, platelets and WBCs, prepare the test samples and the tools/reagents used in the test, examine and interpret the results. K3 2.0 Skills 2.1 Interpret results from common CBC, and select special screening or confirmatory tests in patients with different types of abnormal blood cell morphology. S2 Practical laboratory sessions (hands-on experience will allow students to perform various hematological tests to understand the practical implications of their theoretical knowledge) Case studies (will allow students to analyze lab result and provide accurate interpretation) Practical portfolio Lab reports designed to enable students to recognize, evaluate and challenge their own learning process. - Practical exam - Problem solving questions 2.2 - Case Studies Interpret results from CBC and select differential diagnosis for different types of hematological malignancies such as cytochemical stains, flowcytometry, cytogenetics and other genetic diagnostic tests. S2 3.0 Values, autonomy, and responsibility 3.1 Recommend oral presentation and teamwork work discussion of clinical case study. V3 - Case-Based Learning - Group discussion - Oral Presentations: (Students will be required to orally discuss their research findings and essays) - Laboratory demonstration - Study-case problem Assessment of group assignment/ presentation includes a Component for individual contribution. C. Course Content No List of Topics Contact Hours 19. Hematopoietic stem cell general features, hematopoietic organs processes. Bone marrow structure and functions. 4 20. Erythropoiesis and mature red cell structure and functions and laboratory evaluation. 4 3- Red cell membrane and Metabolism. 4 4. Hemoglobin types, structure, functions, breakdown and Laboratory evaluation. 4 5. Basic Hematological techniques (Hemocytometers and blood cell counts, Hematocrits, Red cell indices ESR). 4 6. Basic Hematological techniques (blood smear preparation, staining and examination). 4 7. Leukopoiesis, leucocytes structures, functions and Laboratory evaluations. 4 8. Thrombopoiesis and platelet structure, function, and laboratory evaluation. 4 9. Iron metabolism (Sources, absorption, transport, function and storage). 4 10. Vitamin B12 (Sources, absorption, transport, function and storage). 4 11. Introduction to anemia. 4 12. Hypochromic anemias 4 13. Macrocytic anemias 4 14. Cases on IDA and macrocytic anemias 4 15. White blood cell benign disorder. 4 60 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 48. Continuous assessment (Assignment/Homework/ Class discussions/ Oral presentation) Ongoing 5% 49. Midterm examination (written) Week 8-9 15% 50. Lab Report Week 14 5% 51. Assignment Week 12 5% 4. Practical exam Week 15-16 30% No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 5. Final theoretical exam Week 17-18 40% *Assessment Activities (i.e., Written test, oral test, oral presentation, group project, essay, etc.). E. Learning Resources and Facilities 1. References and Learning Resources Essential References 1. Hoff brand AV, Pettit JE, PAH Moss (2001). Essential of Hematology. 4th ed, BlackwellScientific Publications, ISBN 0632051531. 2. Sir John V. Deice & Lewis. (2011). Practical Hematology, ISBN-10: 0- 443-066. Supportive References 1. Robert T. Means Jr. MD (Author), Daniel A. Arber MD (Author), Bertil E. Glader MD PhD (Author), Wintrobe’s Clinical Hematology, 15th Edition. 2. Victor Hoffbrand (Editor), Douglas R. Higgs (Editor), David M. Keeling (Editor), Atul B. Mehta (Editor). ISBN: 978-1-118- 85432-7 January 2016 Wiley-Blackwell. Postgraduate Haematology, 7th Edition. Electronic Materials 1. http:// www.med.nagoya-u-ac 2. http:// www.wfh.org/ 3. http:// www.hematology.org/ 4. https://b-s-h.org.uk/ Other Learning Materials as computer-based programs/CD, professional standards or regulations and software 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) Classrooms, Laboratories Technology equipment (projector, smart board, software) Projector, Softboard Other equipment (depending on the nature of the specialty) Water-bath, Centrifuge, Microscopes, multihead training microscopes, auto-cell analyzer, Reagents for routine and special tests, slides of different types of anemias and leukocyte disorders. F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Instructor ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Quality of Learning resources Instructor Student ü Course Report. ü Course Evaluation Survey (CES) Achievement of Course Learning Outcomes Instructor Students ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) ü Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor ü Course Report ü Grade Report Analysis ü Course Evaluation Survey (Indirect) Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)