Course Title: Medical Biochemistry 1 Course Code: CLS 233 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: 2 Last Revision Date: 05/02/1438 A. General information about the course: 1. Course Identification 1. Credit hours: (2) 2 T 2. Course type A. ?University ?College ? Department ?Track ?Others B. ? Required ?Elective 3. Level/year at which this course is offered: (3rd Level/ 2nd year) 4. Course general Description: The course improves the knowledge of students about the metabolism of biomolecules. The course starts by demonstration the role of enzymes in catalyzing metabolic reactions and explaining the production of ATP during the respiratory chain. The students will learn how the carbohydrates, lipids, and protein in the diet are digested, absorbed, and catabolized for production of energy or for production of important building blocks for the human body. Also, they will study the metabolic integration between different pathways during the starvefeed cycle. 5. Pre-requirements for this course (if any): Fundamentals of Medical Biochemistry CLS 115 6. Co-requisites for this course (if any): N/A 7. Course Main Objective(s): 1. Demonstrate enzyme’s structure, functions, its mechanisms of action. 2. Explain the oxidation of reducing equivalents through electron transport chain for production of ATP. 3. Learn the structure and classifications of carbohydrates, lipids, and proteins. 4. Outline different pathways for catabolism of carbohydrates, lipids, and proteins. 5. Understand how the cell synthesizes its requirements from glucose, fatty acids, and amino acids if they are not supplied in the diet. 6. Summarize the major metabolic disorder associated with metabolism of carbohydrates, lipids, and proteins. 7. Illustrate how the human cells and organs integrate between metabolism of carbohydrates, lipids, and proteins. 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 2 100% 2 E-learning No Mode of Instruction Contact Hours Percentage 3 Hybrid • Traditional classroom • E-learning NA NA 4 Distance learning NA NA 3. Contact Hours(based on the academic semester) No Activity Contact Hours 36. Lectures 30 37. Laboratory/Studio 0 38. Field 0 39. Tutorial 0 40. Others (specify) 0 Total 30 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Define enzymes specificity, composition, nomenclature, and mechanism of action. K1 *Lectures are designed to develop directions for extra reading by the students on the topics. *The students are directed to prepare the area of the topic from the textbook. *Presenting power point illustrative figures and pictures related to the topics. • Theoretical exams would contain: • Objective questions (facts recall, Illustrative and /or extended MCQs & fill in blanks). • Short essay questions. 1.2 Identify the structure and classifications of carbohydrates, lipids, and proteins K1 1.3 Recognize the main metabolic pathways and disorders for carbohydrates, proteins, and lipid Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 2.0 Skills 2.1 Develop the ability of students to presentation, teamwork, and sharing of ideas and thoughts. S4 *Discussions during formal lectures and/ or seminars. *Computer and /or problem-based learning. *Oral presentation and discussion of selected research *Problem solving questions. *Group and individual evaluation of internet searches. * Evaluation of group assignment * Evaluation of Active participation in class 3.0 Values, autonomy, and responsibility 3.1 Operate the available computer-based resources including internet and updating their knowledges. V2 • Group and individual internet search and analysis for selected topics • Class discussions. • Regularly reports. • Assignments and Homework. 3.2 Generate teamwork activities, sharing of personal ideas, and making group discussion. V3 C. Course Content No List of Topics Contact Hours 6. v Enzymes specificity, enzyme composition, and nomenclature. v Enzymes classification and theories of interaction between enzyme active site and its substrate. 2 7. v Electron transport chain, its regulation, and inhibitors. 2 3. v Carbohydrates digestion, absorption, and their fate. 2 4. v Glycolysis types, reactions, and Regulation. v Citric acid cycle and its regulation 2 5. v Pentose phosphate pathway and Glycogenesis. v Glycogenolysis and Gluconeogenesis. 2 6. v Lipids digestion and absorption. 2 7. v Fate of absorbed lipids and mobilization of stored TG and Carnitine shuttle. 2 8. v ?-oxidation of fatty acids. v Biosynthesis of fatty acids. 2 9. v Kenton bodies. v Cholesterol metabolism. 2 10. v Proteins structures and classifications. 2 11. v Protein digestion, absorption, and fate of absorbed amino acids. v Deamination of amino acids. 2 12. v Fate of the removed amino group and their transport to liver. v Urea cycle, its regulation, and disorders. 2 13. v Catabolism of carbon skeleton of amino acids and their disorders. v Conversion of amino acids to specialized products. 2 14. v Metabolic integration between carbohydrate, lipids, and protein metabolism. 4 Total 30 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 21. Continuous Assessment: e.g. Quizzes, Internet searches, HomeWorks, Exercises, Class activity, Scratch Cards, Presentations, Group work All over semester 30% 22. Mid-Term exam Week 8-9 20% 23. Assignment Week 12 10% 24. Final Theoretical exam Week 17-18 40% *Assessment Activities (i.e., Written test, oral test, oral presentation, group project, essay, etc.). E. Learning Resources and Facilities 1. References and Learning Resources • Burtis et al., 2000. Teitz textbook of clinical chemistry, Saunders Press. • Mayer et al., 2012. Harper`s biochemistry, Longman Press. • Lippincotts Illustrated Reviews Biochemistry 4thEdition Supportive References • Zilva et al., 2003. Clinical chemistry in diagnosis and treatment, ELBS. Electronic Materials • http://reserveweb.bard.edu • http://bookzz.org/ Other Learning Materials • Audio-Visual Aids. • Selected films/video tapes. • Internet resources. 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) Classrooms Technology equipment (projector, smart board, software) Laptop and data show Other equipment (depending on the nature of the specialty) NA F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Instructor ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Quality of Learning resources Instructor Student ü Course Report. ü Course Evaluation Survey (CES) Achievement of Course Learning Outcomes Instructor Students ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Assessment Areas/Issues Assessor Assessment Methods ü Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor ü Course Report ü Grade Report Analysis ü Course Evaluation Survey (Indirect) Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)