Course Title: Hematology 2 Course Code: CLS 355 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: V2 Last Revision Date: 4/2/1438 H A. General information about the course: 1. Course Identification 1. Credit hours: (3) 2T + 1 P 2. Course type A. ?University ?College xDepartment ?Track ?Others B. x Required ?Elective 3. Level/year at which this course is offered: (5th level/3rd year) 4. Course general Description: This course provides the basic knowledge and skills required for laboratory diagnosis of the different types of hemolytic anemia, hematologic malignancies, including leukemias (acute and chronic types), myeloproliferative neoplasms, MDS, lymphoid and plasma cell malignancies. In addition, the course gives in-depth understanding of how to calculate and interpret the given results, based on complete blood count, peripheralblood picture. Also, special hematological tests such as for anemias such sickling and Hb S solubility test and special tests to diagnose hematologic malignancies such cytochemical stains, cytogenetic and immunophenotyping will be included in the course. 5. Pre-requirements for this course (if any): Hematology 1 (CLS 246) 6. Co-requisites for this course (if any): None 7. Course Main Objective(s): • Classify hemolytic anemias and Enumerate RBC membrane defects and discuss hereditary spheocytosis, elliptocytosis, stomatocytosi, ovalocytosis, and other membrane defect hemolytic anemias. • List RBC enzymopathies and describe glucose 6 phosphate dehydrogenase andPyruvate Kinase deficiency anemias. • Outline and describe different types of hemoglobinpathies and discuss sickle hemoglobinopathies. • Describe acquired hemolytic anemias. • Classify and discuss immune hemoytic anemias including Paroxysmal nocturnal hemoglobinuria(PNH) and paroxysmal cold hemolglobinuria (PCH). • Outline and explain the different types of thalassemia syndromes. • Describe WBC benign disorders and discuss leukemia, myeloproliferative neoplasms, myelodysplasia, lymphomas and plasma cell malignancies. • Describe and list WHO classification for hematopoietic and lymphoid neoplasms. 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 60 100 2 E-learning 3 Hybrid • Traditional classroom • E-learning 4 Distance learning 3. Contact Hours(based on the academic semester) No Activity Contact Hours 101. Lectures 30 102. Laboratory/Studio 30 103. Field 104. Tutorial 105. Others (specify) Total 60 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Classify and distinguish different types of hemolytic anemias K1 Comprehensive Lectures (to cover the basic aspects, classification and pathophysiology of hemolytic anemias, benign and malignant leukocyte disorders, using visuals, diagrams, and multimedia presentations to enhance understanding of complex concepts Break down the information into manageable segments to facilitate learning. Theoretical exams would contain: • Objective questions (Factual recall, illustrative and/or extended MCQs & fill in blanks). 1.2 describe different types of hematological malignancies including different types of leukemias, MPN, MDS, lymphomas and plasma cell malignanci Code Course Learning Outcomes Code of CLOs program Teaching Strategies Assessment Methods - Case-Based Learning (Integrate case studies into the curriculum to illustrate reallife scenarios of anemias and hematologic malignancies. Encourage students to analyze and discuss cases, applying theoretical knowledge to practical situations). - Group discussion ( to initiate problem solving challenges among groups). • Short essay questions • Long essay questions 2.0 Skills 2.1 Apply tests and interpret results from common CBC and select special screening or confirmatory tests in patients with different types of anemias. S1 Practical laboratory sessions (hands-on experience will allow students to perform various hematological tests to understand the practical implications of their theoretical knowledge) Case studies (will allow students to analyze lab result and provide accurate interpretation) Practical portfolio Lab reports designed to enable students to recognize, evaluate and challenge their own learning process. - Practical exam - Problem solving questions 2.2 - Case Studies Interpret results from CBC and select differential diagnosis for different types of hematological malignancies such as cytochemical stains, flowcytometry, cytogenetics and other genetic diagnostic tests S2 3.0 Values, autonomy, and responsibility 3.1 Manage the importance of ethical considerations when conducting laboratory tests related to anemias and leukemias and other hematological neoplasms. V1 - Case-Based Learning - Group discussion - Laboratory demonstration - Study-case problem Assessment of group assignment/ presentation includes a Component for individual contribution. 3.2 Modify variable web sites searching to complement extra information education. V2 C. Course Content No List of Topics Contact Hours 24. Classification of hemolytic anemias and discuss membrane defect anemias. 4 25. Types of red cell enzymopathies including G6PD and pyruvate kinase deficiency. 4 3- Hemoglobinopathies: sickle hemoglobinopathies and other types, genetic defects, pathophysiology, clinical outcome, different lab diagnostic measures. 4 4. Acquired hemolytic anemia types: non immune types 4 5. Immune hemolytic anemias: cold types (PCH and CHAD disease) 4 6. Warm type immune hemolytic anemias: autoimmune, HDN, HTR 4 7. Benign leukocyte disorders: Inherited and acquired, Quantitative and qualitative 4 8. Introduction and classification of leukemias and WHO classification of hematopietic and lymphoid neoplasms 4 9. Acute lymphoblastic leukemia. 4 10. Acute myeloid leukemia 4 11. Chronic myeloid and lymphoid leukemias 4 12. Myeloproliferative neoplasms (MPNs) 4 13. Myelodysplastic syndromes (MDS) 4 14. Plasma cell malignancies 4 15. Hodgkin's and non-Hodgkin's lymphomas (WHO types) 4 Total 60 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 65. Continuous assessment All over semester 5% 66. Midterm examination (written) Week 8-9 15% 67. Assignment Week 12 5% 4. Lab report Week 14 5% 5. Practical exam Week 15-16 30% 6. Final exam Week 17-18 40% E. Learning Resources and Facilities 1. References and Learning Resources Essential References 3. Hoff brand AV, Pettit JE, PAH Moss (2001). Essential of Hematology. 4th ed, BlackwellScientific Publications, ISBN 0632051531. 4. Sir John V. Deice & Lewis. (2011). Practical Hematology, ISBN-10: 0- 443-066. 5. Shirlyn B. McKenzie, PhD, CLS (NCA), (2014) . Clinical Laboratory Hematology,3ed Edition University of Texas Health Science center at San Antonio, Lynne Williams. Supportive References 3. Robert T. Means Jr. MD (Author), Daniel A. Arber MD (Author), Bertil E. Glader MD PhD (Author), Wintrobe’s Clinical Hematology, 15th Edition. 4. Victor Hoffbrand (Editor), Douglas R. Higgs (Editor), David M. Keeling (Editor), Atul B. Mehta (Editor). Postgraduate Haematology, 7th Edition. ISBN: 978-1-118-85432-7 January 2016 WileyBlackwell. Electronic Materials 1. http:// www.med.nagoya-u-ac 2. http:// www.wfh.org/ 3. http:// www.hematology .org/ 4. https://b-s-h.org.uk/ Other Learning Materials as computer-based programs/CD, professional standards or regulations and softwar 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) Classrooms, Laboratories Technology equipment (projector, smart board, software) Projector, Softboard Other equipment (depending on the nature of the specialty) Water-bath, Centrifuge, Microscopes, multihead training microscopes, auto-cell analyzer, Reagents for routine and special tests, slides of different types of anemias and leukocyte disorders. F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Instructor ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Quality of Learning resources Instructor Student ü Course Report. ü Course Evaluation Survey (CES) Achievement of Course Learning Outcomes Instructor Students ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) ü Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor ü Course Report ü Grade Report Analysis ü Course Evaluation Survey (Indirect) Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)