Course Title: Medical Virology Course Code: CLS 366 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: Version 2 Last Revision Date: 07/01/1438 AH A. General information about the course: 1. Course Identification 1. Credit hours: (3) 2 T + 1 P 2. Course type A. ? University ? College ? Department ?Track ?Others B. ? Required ?Elective 3. Level/year at which this course is offered: (6th Level/3rd Year) 4. Course general Description: This course provides an in-depth understanding of how viruses cause diseases in humans, the molecular biology of viruses, and their interactions with host organisms. The course enables the students of understanding viruses' roles in cancer, immunology, neuromuscular diseases, vaccines, epidemiology, emerging and reemerging viruses, pandemic preparedness, and public health response to viral outbreaks. This course also enables students to demonstrate diagnostic practice of viral infections, including cell culture and molecular and serologic testing. The students will be also introduced to the implication of viral diseases on global health, and how the scientific community tackles viral outbreaks, including prevention and containment. 5. Pre-requirements for this course (if any): Medical Microbiology CLS 242 6. Co-requisites for this course (if any): N/A 7. Course Main Objective(s): 1. Define basic principles of Virology: Students will gain foundational knowledge of basic virology including definitions, classification, structure, morphology, and molecular biology of viruses. 2. Develop knowledge of Viral Pathogenesis: Students will learn how viral infections lead to disease at the cellular, tissue, and host levels, the effects of the immune response on the outcome of infection, and various clinical manifestations associated with specific viral pathogens. 3. Define basic principles of diagnostic Virology: The course provides students with the necessary skills to perform and interpret various laboratory techniques used in the diagnosis of viral infections including cell culture, serological and molecular techniques. The student will correlate these techniques with infectious diseases, prevention, and control measures of infection. 4. Develop knowledge of viral diseases management and prevention: The course effectively explains viral diseases, their spread, and prevention measures to the public. This objective is important for reducing disease-related misunderstandings and panic and promoting public health awareness. 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 60 100% 2 E-learning 3 Hybrid • Traditional classroom • E-learning 4 Distance learning 3. Contact Hours(based on the academic semester) No Activity Contact Hours 132. Lectures 30 133. Laboratory/Studio 30 134. Field 135. Tutorial 136. Others (specify) Total 60 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Describe Basic Virology Concept and principles, including virus structure, classification, viral diseases and diagnosis K1 Theory lectures+ online materials+ practical sessions 1-Wirtten exams (essays and MCQs) 2-Presentation 1.2 Demonstrate viral replication, pathogenesis, and K2 Theory lectures + online materials 1-Wirtten exams (essays and MCQs) 2-Presentation Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods epidemiology, including emerging and re-emerging viruses. 3-Objective Practical Exam 2.0 Skills 2.1 Apply proper approaches in the diagnosis of viral infections S1 Theory Lectures + Case-based learning + practical sessions + Group discussion 1-Wirtten exams (essays and MCQs) 2-Objective Practical Exam 2.2 Evaluate diverse pathological features of viral diseases to develop professional judgment and interpretive skills S3 Theory Lectures + Case-based learning + practical sessions + Group discussion 1-Wirtten exams (essays and MCQs) 2-Objective Practical Exam 2.3 Apply safety measures and quality standards of the virology laboratory S4 Theory Lectures + Case-based learning+ practical sessions + Group discussion 1-Wirtten exams (essays and MCQs) 2-Objective Practical Exam 3.0 Values, autonomy, and responsibility 3.1 Apply academic research in the field of medical virology V1 Practical sessions + Case-based learning + Assignment 1-Assignments 2-Objective Practical Exam C. Course Content No List of Topics Contact Hours Therotical Sessions 51. Introduction to viruses and general properties of viruses 2 52. Viral replication cycle and Virus Genetics Virus cell culture and its effect 2 3. Serological and Molecular Virus Diagnosis 2 4. Herpesviruses and Parvovirus 2 5. Adenoviruses 2 6. Orthomyxovirsues 2 7. Paramyxoviruses and other respiratory viruses 2 8. Lentiviruses (HIV and HTLV) 2 9. Hepatitis viruses B and D 2 10. Hepatitis viruses A, E and C 2 11. Rabies virus and poliovirus 2 Rotavirus and other gastrointestinal viruses 2 13. Oncogenic viruses 2 14. Hemorrhagic viruses 2 15 Emerging viruses, slow viruses and prions 2 Practical Sessions 1. Tools of identification (Quantitative & Qualitative) 2 2. Methods of cultivation of viruses Tissue culture 2 3. Methods of cultivation of viruses; Embryonated eggs and Intact animals 2 4. Virus plaque Assay 2 5. Virus detection in cell culture – Virus cytopathic effect 2 6. Detection of virus: Haemadsorption 2 7. Neutralization Assay 2 8. Fluorescent Assay and Antibody staining 2 9. ELISA Assay 2 10. Hybridization Assay 2 11. Introduction to Molecular virus diagnosis 2 12. Conventional PCR and Real Time PCR 2 13. RT-PCR 2 14. Sequencing and Pyhlogenicity 2 15. Modern technology in virus diagnosis 2 Total 60 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 87. Continuous assessment (Quiz) Week 4 5% 88. Mid term Week 8-9 15% 89. Assignment Week 12 5% 90. Lab Reports Week 14 5% 4. Practical exam Week 15-16 30% 5. Final exam Week 17-18 40% E. Learning Resources and Facilities 1. References and Learning Resources Essential References 1- Medical Microbiology (9th Edition) By Patrick R. Murray PhD 2- Jawetz, Medical Microbiology 26th Edition Supportive References Fields' Virology, by David Mahan Knipe, Peter M. Howley. The 5th edition. Electronic Materials N/A Other Learning Materials N/A 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) Classrooms laboratories Technology equipment (projector, smart board, software) - Computer - Data show - Smart Board - Network for technology transfer. Other equipment (depending on the nature of the specialty) Nil F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Instructor ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) Effectiveness of Students' assessment Head of the department Student achievement is verified by the head of the department. Quality of Learning resources Instructor Student ü Course Report. ü Course Evaluation Survey (CES) Assessment Areas/Issues Assessor Assessment Methods Achievement of Course Learning Outcomes Instructor Students ü Direct Method (Rubrics) ü Indirect Method (Questionnaire on the course by the end of the semester) ü Course Evaluation Survey (CES) Effectiveness of Assessment Results Instructor ü Course Report ü Grade Report Analysis ü Course Evaluation Survey (Indirect) Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)