Course Title: Fundamentals of Medical Biochemistry Course Code: CLS 115 Program: Clinical Laboratory Sciences Department: Clinical Laboratory Sciences College: Applied Medical Sciences Institution: Taibah University Version: 1 Last Revision Date: N/A A. General information about the course: 1. Course Identification 1. Credit hours: (2) 2 T 2. Course type A. ?University ? College ? Department ?Track ?Others B. ? Required ?Elective 3. Level/year at which this course is offered: (Level 1/year 1) 4. Course general Description: This course provides the fundamental understanding of the structures and classifications of carbohydrates, lipids, proteins, enzymes, and nucleic acids. The course also describes the biological roles of these biomolecules in a well-rounded foundation of biochemical knowledge. This course covers the biological importance of water, pH, and buffers of the biological fluids as well as the units used in measuring concentrations. 5. Pre-requirements for this course (if any): NA 6. Co-requisites for this course (if any): NA 7. Course Main Objective(s): • To describe the structure, classifications and function of carbohydrates, lipids, proteins, nucleic acids, and enzymes. • To explain the relationship between the structure of biomolecules and their respective functions. • To highlight the function of water, pH, and buffer in biological fluids. • To explain the basics of the standard units used in measuring concentrations. 2. Teaching mode (mark all that apply) No Mode of Instruction Contact Hours Percentage 1 Traditional classroom 30 100% 2 E-learning 0 0 3 Hybrid • Traditional classroom • E-learning 0 0 4 Distance learning 0 0 3. Contact Hours(based on the academic semester) No Activity Contact Hours 11. Lectures 30 12. Laboratory/Studio 0 13. Field 0 14. Tutorial 0 15. Others (specify) 0 Total 30 B. Course Learning Outcomes (CLOs), Teaching Strategies and Assessment Methods Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 1.0 Knowledge and understanding 1.1 Explain the structure, classifications and the biological functions of carbohydrates, lipids, proteins, nucleic acid, and enzymes. K1 • Lectures • Multiple choice questions (MCQs) • Short essay questions 1.2 Identify the standard units used in measuring concentration. K2 • Lectures • Multiple choice questions (MCQs) • Short essay questions 2.0 Skills Code Course Learning Outcomes Code of CLOs aligned with program Teaching Strategies Assessment Methods 2.1 Discuss the functions of carbohydrates, proteins, lipids, nucleic acids, water, and buffers in human body. S3 • Lectures • Multiple choice questions (MCQs) • Short essay questions 2.2 Differentiate between the chemical structures and function of different biomolecules. S3 • Lectures • Multiple choice questions (MCQs) • Short essay questions 3.0 Values, autonomy, and responsibility 3.1 Utilize the basic biochemical concepts and principles in human health applications. V2 • Lectures • Multiple choice questions (MCQs) • Short essay questions • Assignments C. Course Content No List of Topics Contact Hours 1 Importance of Biochemistry in Medicine: Introduction to biomolecules. 2 2 Biological Roles and General Classification of Carbohydrates I: Structure, classification, and functions of monosaccharides and its derivatives. 2 3 Biological Roles and General Classification of Carbohydrates II: Structure, occurrence, classification, and importance of disaccharides and polysaccharides. 2 4 Biological Importance and Structure of Amino Acids I: Classifications of amino acids, non-proteinogenic amino acids and its biological roles. 2 5 Biological Importance and Structure of Amino Acids II: 2 Peptide formation, peptide classification, biologically active peptides, biological importance of proteins, Types of interactions between amino acid residues in the protein. 6 Biological Importance and Structure of Amino Acids III: Levels of structural organization of proteins, globular proteins versus fibrous proteins 2 7 Enzymes: Enzyme’s structure, composition, and classification, regulation of enzyme activity 2 8 Lipid Classification and Biological Importance of Lipids I: Fatty acid structure, classification, and nomenclature. 2 9 Lipid Classification and Biological Importance of Lipids II: Structure, types, and biological importance of triglycerides, phospholipids, sphingolipids, glycolipids, cholesterol, and derived lipids 2 10 Structure and Types of Purine and Pyrimidine Bases: Structure, types, and biological importance of purine and pyrimidine nucleotides. 2 11 Structure, Types, and Function of DNA and RNA: Central dogma of life (flow of genetic information), DNA denaturation and renaturation. 2 12 Water and Its Importance in Tissues and Biological Fluids: PH of solution and physiological pH 2 13 Buffers Composition and Function: Types of buffers in biological fluids. 2 14 Standard Units of Concentrations: 2 15 Emerging Trends and Research in Medical Chemistry 2 Total 30 D. Students Assessment Activities No Assessment Activities * Assessment timing (in week no) Percentage of Total Assessment Score 7. Continuous Assessment Ongoing 30% 8. Midterm exam Week 8-9 20% 9. Group project, Oral presentation, assignment Week 12 10% 4. Final exam Week 17-18 40% *Assessment Activities (i.e., Written test, oral test, oral presentation, group project, essay, etc.). E. Learning Resources and Facilities 1. References and Learning Resources Essential References • Lehninger “principles of Biochemistry”, David Nelson and Michael Cox. 7th.Ed. (2017) • “Biochemistry”,Lubert Stryer. 9th.Ed.(2019) • Basic Methods for Biochemical Lab (Springer Lab Manual). Martin Holtzhauer; Springer, 1E. 2006. Supportive References • Biochemistry The Molecular Basis of Life, McGraw-Hill North Amer. ' 3rd.Ed. (2003) Trudy Makee and James R.Makee. Electronic Materials • http://reserveweb.bard.edu • https://www.khanacademy.org/science/biology • https://sdl.edu.sa/SDLPortal/Publishers.aspx Other Learning Materials • Audio-Visual Aids. • Selected films/video tapes. • Internet resources. 2. Required Facilities and equipment Items Resources facilities (Classrooms, laboratories, exhibition rooms, simulation rooms, etc.) Classrooms + Laboratories Technology equipment (projector, smart board, software) Projector + Smart board Other equipment (depending on the nature of the specialty) F. Assessment of Course Quality Assessment Areas/Issues Assessor Assessment Methods Effectiveness of teaching Peer Reviewer Direct Effectiveness of Students assessment Faculty Direct (cross-check) Quality of learning resources Students Indirect (course evaluation) The extent to which CLOs have been achieved Course Coordinator Direct Other Peer Reviewer Direct Assessors(Students, Faculty, Program Leaders, Peer Reviewer, Others (specify) Assessment Methods(Direct, Indirect)